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Review Article


Gut microbiota and its role in cancer patients

Ankita Purkite
General Practitioner, Vadodara, Gujarat, India
Corresponding Author:

Ankita Purkite

General Practitioner, Vadodara, Gujarat, India
E-mail: ankita.purkite@gmail.com

Corresponding Author:

Ankita Purkite

General Practitioner, Vadodara, Gujarat, India
E-mail: ankita.purkite@gmail.com

DOI:10.18203/issn.2456-3994.IntJMolImmunoOncol20180467

ABSTRACT


Chemotherapy and allogeneic stem cell transplant suppress the body’s immunity making them more prone to neutropenic sepsis, for which the patients have to be given broad-spectrum antibiotics. These antibiotics disrupt the well-organized colony of our intestinal microbiome creating dysbiosis. Dysbiosis makes the intestine a favorable platform for certain Gram-positive bacilli to proliferate which is Clostridium difficile. Traditional treatment requires the patient to take metronidazole, vancomycin, and probiotics. Recurrent C. difficile infection makes the traditional treatment a failure. Thus, fecal microbial transplant is the answer to recurrent C. difficile.
Keywords: Allogeneic-hematopoietic stem cell transplant, Clostridium difficile, Chemotherapy, Dysbiosis, Fecal microbiota transplantation

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