Go Back This article was viewed 32 times

Review Article


Molecular markers in thyroid cancers

Alpa Nimesh PatelSiddharth Singh
Department of Internal Medicine, Pramukhswami Medical College, Karamsad, Anand, Gujarat, India
Corresponding Author:

Alpa Nimesh Patel

Department of Internal Medicine, Pramukhswami Medical College, Karamsad, Anand, Gujarat, India
E-mail: alpa@charutarhealth.org

Corresponding Author:

Alpa Nimesh Patel

Department of Internal Medicine, Pramukhswami Medical College, Karamsad, Anand, Gujarat, India
E-mail: alpa@charutarhealth.org

DOI:10.18203/issn.2456-3994.IntJMolImmunoOncol20172639

ABSTRACT


Thyroid cancer is the most common of all endocrine tumors. In most countries, a steady increase in the incidence of thyroid cancer (mainly papillary carcinomas) was observed in both sexes, whereas mortality has declined. Thyroid nodule is the most common presentation of thyroid cancer and according to Bethesda reporting system is categorized into six different disease categories based on histopathological pattern. The indeterminate categories require further investigation which is generally in the form of a surgical or invasive procedure for confirmation of nature of disease. Our article is describing the various molecular markers that are linked with different subtypes of thyroid cancer and their usage in guiding diagnosis, investigative approach and prognostication in thyroid cancer especially the indeterminate categories. We discuss the various tests available for us currently for detecting the genetic alterations and thus help us frame further approach algorithms for detection of thyroid cancers
Keywords: Afirma, Molecular markers, Thyroid cancer, ThyroSeq