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Review Article


Molecular diagnosis of pediatric tumors

Tanushri MukherjeeSoma MukherjeeRajat Dutta
Department of Pathology, Command Hospital, Chandimandir, Panchkula, Haryana1Deparment of Obstetrics and Gynaecology, AIIMS, Bhopal, Madhya Pradesh, 3Department of Surgery, Command Hospital, Kolkata, West Bengal, India, 
Corresponding Author:

Tanushri Mukherjee

Department of Pathology, Command Hospital, Chandimandir, Panchkula, Haryana
E-mail: tanujamukherjee@yahoo.com

Corresponding Author:

Tanushri Mukherjee

Department of Pathology, Command Hospital, Chandimandir, Panchkula, Haryana
E-mail: tanujamukherjee@yahoo.com

DOI:10.18203/issn.2456-3994.IntJMolImmunoOncol20172638

ABSTRACT


Pediatric tumors are challenging in the context of best diagnosis, treatment, and prognosis. For tumors which have a genetic association or a cancer predisposition syndrome, the prognosis depends on accurate diagnosis. The application of molecular genetics to pediatric tumors has resulted in better diagnostic and prognostic factors for patient management. Molecular diagnostic techniques, such as reverse transcription polymerase chain reaction and fluorescence in situ hybridization (FISH), have become important tests for childhood tumors. Targeted therapies are aimed at specific translocations which are detected by FISH. Molecular techniques help in monitoring of minimal residual disease in childhood tumors.
Keywords: Fluoresence in situ hybridization, Paediatric tumors, RTPCR