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Original Article


Clinical profile and role of VEGF-c polymorphism in prognosis and management of breast cancer

Amulya SinghGulab Dhar YadavAnand Narayan SinghShashwat TiwariVimal Choubey
Departments of General Surgery1Biochemistry, GSVM Medical College, Uttar Pradesh, India, 
Corresponding Author:

Amulya Singh

Department of General Surgery, GSVM Medical College, Uttar Pradesh, India
E-mail: Singhamulya1@gmail.com

Corresponding Author:

Amulya Singh

Department of General Surgery, GSVM Medical College, Uttar Pradesh, India
E-mail: Singhamulya1@gmail.com

DOI:10.18203/issn.2456-3994.IntJMolImmunoOncol20170053

ABSTRACT


Purpose: Angiogenesis is a necessary step in tumor growth and metastasis. Vascular endothelial growth factor (VEGF-c) is a major mediator of breast cancer angiogenesis. Therefore, we investigated the association of polymorphism in the VEGF-c gene with breast cancer risk and prognostic characteristics of the tumors in a case-control study. Experimental Design: We examined one polymorphism in the VEGF-c gene (+936C/T) in 75 breast cancer cases and 75 control from Kanpur, Uttar Pradesh, India and adjacent areas together with geographically selected controls. Results: None of the polymorphism or any haplotype was significantly associated with either breast cancers. Our study suggests that the +936C/T polymorphism is unlikely to be associated with breast cancer. We also analyzed the cases for genotypes or haplotypes that associated with tumor characteristics. The genotypes and haplotypes were not related with other tumor characteristics such as regional or distant metastasis, stage at diagnosis, or dietary history. Conclusions: Although none of the polymorphisms studied in the VEGF-c gene was found to influence susceptibility to breast cancer significantly, some of the VEGF-c genotypes and haplotypes may influence tumor growth through an altered expression of VEGF-c and tumor angiogenesis.
Keywords: Polymorphism, VEGF-c, Breast cancer, Indian population