Go Back This article was viewed 95 times

Original Article


A molecular approach to Glioblastoma Multiforme

Amit VermaSwetha GunasekarVineeta GoelRandeep SinghRamandeep Singh AroraNitesh RohatgiA. K. AnandMeenu Walia
Consultant, Molecular Oncology & Cancer Genetics1Genetic Counselor & Research Coordinator, 2Consultant, Radiation Oncology, 3Senior Consultant Medical Oncology, HCG, New Delhi, 4Consultant Pediatric Oncologist, 5Consultant Medical Oncology, 6Director & Senior Consultant, Radiation Oncology, 7Director & Senior Consultant, Medical Oncology, Max Hospitals, NewDelhi, India, 
Corresponding Author:

Amit Verma

Consultant, Molecular Oncology & Cancer Genetics, Medical Oncology, Max Hospitals, NewDelhi, India
E-mail: amitverma.dr@gmail.com

Corresponding Author:

Amit Verma

Consultant, Molecular Oncology & Cancer Genetics, Medical Oncology, Max Hospitals, NewDelhi, India
E-mail: amitverma.dr@gmail.com

DOI:10.18203/issn.2456-3994.IntJMolImmunoOncol20164387

ABSTRACT


Glioma is a tumor of the central nervous system that occurs in the glial cells, Which it surrounds and protects the nerve cells. Glioblastoma Multiforme (GBM) is the most common and malignant sub-type of gliomas that arises from star-shaped cells called “astrocytes”, which constitute the supportive tissue of the brain. GBM are known to be heterogeneous in outcome with majority having a poor prognosis, thus there is an urgent need for novel therapeutic approaches. The detailed understanding of GBM is established by the combination of histopathology and genomic information of the tumor that aids in the best choice of Personalized Medicine. In this article, seven GBM patients are discussed who underwent tissue diagnosis as well as tumor molecular profiling; the significance of the genes and associated mutations/variations picked up in each individual.
Keywords: Brain, Genes, Genetic testing, Glioblastoma multiforme, Glioma, Mutations, Personalized medicine